Welcome to the ultimate guide for creating the irresistible John Wayne Casserole! This beloved dish is more than just an easy ground beef casserole; it’s a flavorful journey combining hearty ingredients with comforting textures. Imagine a tender, buttery biscuit base, generously topped with seasoned ground beef, vibrant diced tomatoes, crisp onions, a rich blend of cheeses, and the creamy tang of sour cream. Each bite delivers a burst of classic flavors, making it a staple for family dinners and a go-to for anyone seeking a satisfying, no-fuss meal. This casserole perfectly encapsulates the spirit of simple, yet incredibly delicious, home cooking.

John Wayne Casserole: A Hearty Family Favorite
The John Wayne Casserole, famously named after the legendary Western actor, truly embodies the essence of robust, satisfying American cuisine. It stands out among easy ground beef casseroles for its unique biscuit base, providing a delightful foundation that sets it apart from typical pasta or rice-based dishes. Layered generously with savory ground beef, zesty Rotel diced tomatoes and green chilies, sweet corn, flavorful bell peppers, and an indulgent combination of sour cream, mayonnaise, and cheese, this dish is a symphony of textures and tastes. It’s the kind of comfort food that brings everyone to the table, making it a perennial favorite for busy weeknights or relaxed weekend meals.
This hearty casserole is a testament to the power of simple ingredients creating extraordinary flavor. When you have ground beef needing a delicious purpose, this recipe is a top contender. Its versatility is another key selling point; you can easily adapt it using ingredients already in your pantry, transforming it into a personalized family meal. Think of it as a deconstructed beef fajita or a Tex-Mex inspired delight, all conveniently baked into one dish. The ability to customize ensures that even picky eaters will find something to love, making it an excellent choice for any household.
One of the true stars of this ground beef casserole is its Bisquick baking mix base. This ingenious shortcut ensures a consistently fluffy and delicious biscuit crust that bakes up perfectly every time. Bisquick is a kitchen hero, capable of transforming into a wide array of baked goods. From fluffy Bisquick Waffles and delectable Bisquick Peach Cobbler to convenient Pancake Muffins and rustic Bisquick Beer Bread, the possibilities are endless. Many households, ours included, keep giant boxes of Bisquick on hand, especially from places like Costco, because its versatility and reliable deliciousness make it an indispensable ingredient for countless recipes.
The history behind this particular casserole adds to its charm. It’s rumored that John Wayne himself contributed this very recipe to a 1979 cookbook titled “Cooking with Love from Cara and her Friends,” compiled by author Cara Connery. This intriguing tidbit makes the dish even more special, connecting it to an American icon and a simpler era of home cooking. For those who enjoy collecting vintage cookbooks, finding a copy of Cara Connery’s compilation would be a delightful treasure, much like discovering other beloved recipes in old church or community cookbooks. Such culinary artifacts offer a fascinating glimpse into the past and often yield timeless, comforting dishes just like this one.
Whether you’re a seasoned chef or a beginner in the kitchen, the John Wayne Casserole offers an approachable and rewarding cooking experience. Its assembly is straightforward, allowing you to quickly create a wholesome meal with minimal fuss. The combination of savory meat, vibrant vegetables, and creamy, cheesy layers all baked atop a golden biscuit crust makes for a truly satisfying dish that will quickly earn a permanent spot in your family’s recipe rotation. Prepare to impress your taste buds and gather your loved ones around a comforting meal that celebrates both ease and incredible flavor.

Ingredients for Your John Wayne Casserole Adventure
Crafting an epic John Wayne Casserole starts with a selection of simple, readily available ingredients. This dish doesn’t require exotic spices or hard-to-find components, ensuring it’s accessible for every home cook. Here’s a detailed look at what you’ll need, along with some insights into how each ingredient contributes to the final masterpiece:
- Ground Beef: The foundation of this hearty casserole. We recommend a lean ground beef (80/20 or 90/10) to minimize excess grease, but any ground beef will work. You’ll drain the fat later, ensuring a clean, rich flavor.
- Taco Seasoning: This packet of magic infuses the ground beef with authentic Tex-Mex flavor, adding depth and a mild spice that perfectly complements the other ingredients. Choose your preferred brand or even a homemade blend.
- Rotel Diced Tomatoes and Green Chilies: This iconic canned ingredient provides a beautiful balance of acidity from the tomatoes and a subtle kick from the green chilies. Make sure to drain them well to prevent a watery casserole.
- Corn: Canned or frozen corn adds a touch of sweetness and a pleasant textural contrast to the savory beef and creamy layers. Drain canned corn thoroughly.
- Bisquick Biscuit Mix: The secret to the incredibly easy and delicious biscuit base. It eliminates the need for making dough from scratch, saving time and ensuring a consistent result every time.
- Sour Cream: This contributes to the rich, creamy, and slightly tangy topping that makes this casserole so decadent. Full-fat sour cream offers the best flavor and texture.
- Cream Cheese: While not explicitly listed in the original ingredients list, the instruction for a “cream cheese mixture” suggests it’s intended. Cream cheese adds an extra layer of velvety smoothness and tang to the topping, enhancing its richness significantly. We will incorporate it into the sour cream mixture for an even more luxurious texture.
- Cheddar Cheese or Sharp Cheddar Cheese: The quintessential topping that melts into a gooey, golden crust. Shredded cheddar cheese adds a sharp, savory note that completes the dish. Feel free to use mild or sharp, depending on your preference.
- Mayonnaise: Blended with sour cream, mayonnaise adds another dimension of creaminess and a subtle richness to the topping. Use your favorite brand for the best results.
- Red Bell Peppers or Green Bell Peppers: Diced bell peppers bring fresh crunch and a pop of color, along with a mild, sweet flavor that harmonizes beautifully with the seasoned beef. Green bell peppers are traditional, but red, yellow, or orange can also be used for a sweeter flavor.
- Onion Powder: To ensure a consistent onion flavor throughout the creamy layer without the texture of diced onions, onion powder is a fantastic addition.
- Salt: A fundamental seasoning to enhance all the flavors in the sour cream and mayonnaise mixture.
Optional additions: Elevate your John Wayne Casserole with extra ingredients like sliced black olives for a briny touch, canned black beans (rinsed and drained) for added protein and fiber, or sliced jalapeño peppers for a spicier kick. Just remember to account for these additions when selecting your casserole dish size!
Essential Equipment Needed for Casserole Success
Having the right tools can make all the difference in preparing this John Wayne Casserole efficiently and safely. Here’s a rundown of the equipment you’ll need, along with some helpful notes:
- Large Skillet: Indispensable for browning your ground beef and combining the meat mixture. A non-stick skillet can make cleanup easier.
- Large Spoon: For stirring, mixing, and serving. A sturdy wooden or heat-resistant silicone spoon is ideal.
- Large Mixing Bowl: You’ll need one for preparing the Bisquick dough and another for mixing the sour cream topping. We highly recommend a glass batter bowl with a handle, as it provides stability while mixing and makes pouring easier.
- Hamburger Chopper (Meat Chopper): This tool is a game-changer for breaking up ground beef evenly as it cooks. It’s incredibly versatile and will quickly become one of your most used kitchen gadgets for various recipes.
- 9×13-Inch Baking Dish: The standard size for most casseroles, providing ample space for all the delicious layers. Make sure it’s oven-safe and can withstand the baking temperature.
- Heat-Resistant Potholders: Safety first! Investing in good quality, heat-resistant potholders is crucial. We learned this lesson the hard way after a near-miss with a cloth potholder catching fire. These will protect your hands and ensure safe handling of hot dishes.
- Non-Stick Cooking Spray: Essential for greasing the casserole dish to prevent sticking and making serving a breeze. It’s also helpful to spray your hands lightly when pressing the Bisquick dough into the pan, preventing stickiness.
- Spider Strainer: An excellent tool for easily removing cooked ground beef from the skillet while leaving behind the rendered fat and grease. It’s more efficient than tilting the pan and ensures a less greasy casserole.
- Baking Sheets with Sides: We are huge advocates for placing your casserole dish on a baking sheet while it bakes. This simple step catches any potential drips or spills from the bubbling casserole, especially if it’s filled to the brim, keeping your oven clean and preventing smoke from burnt residue.
How to Prepare Your John Wayne Casserole: A Step-by-Step Guide
Making this John Wayne Casserole is a straightforward process, designed to bring a delicious meal to your table with ease. Follow these steps for perfect results:

Step 1: Prepare the Ground Beef. Begin by browning the ground beef in a large skillet over medium heat. As it cooks, use a Hamburger Chopper to break it into small, even crumbles. Once fully browned, drain any excess fat and grease from the pan. This is crucial for a non-greasy casserole. Return the lean ground beef to the skillet and stir in the taco seasoning along with 1 cup of water. Allow the mixture to simmer for about 5 minutes, letting the beef absorb all the savory flavors. Then, add the drained Rotel diced tomatoes and green chilies, the drained corn, and the diced bell peppers. Mix well and cook together for a few more minutes until heated through.

Step 2: Prepare the Biscuit Base. While the beef mixture is simmering, combine the Bisquick biscuit mix with 1 cup of water in a large mixing bowl. Stir until a soft dough ball forms. Lightly grease a 9×13-inch casserole dish with non-stick cooking spray. Using your hands (you might lightly spray them too to prevent sticking), press the Bisquick dough evenly into the bottom of the prepared dish, forming a solid base for the casserole.

Step 3: Assemble the Casserole. Evenly spread the seasoned ground beef and vegetable mixture over the Bisquick dough in the casserole dish. In a separate bowl, whisk together the sour cream, mayonnaise, onion powder, and salt until smooth and well combined. Gently spread this creamy mixture over the beef layer, ensuring an even coating. Finally, generously sprinkle the shredded cheddar cheese over the sour cream layer, covering the entire surface of the casserole.

Step 4: Bake to Golden Perfection. Preheat your oven to 325 degrees Fahrenheit (160 degrees Celsius). Place the assembled casserole dish on a baking sheet with sides. This is a crucial step to catch any potential drips or spills as the casserole bakes, especially since the Bisquick dough tends to rise, pushing the other layers higher in the dish. Bake for approximately 40 minutes, or until the biscuit base is cooked through, the beef mixture is bubbly, and the cheese is melted and golden brown. If the cheese starts to brown too quickly, you can loosely tent the dish with aluminum foil.

Step 5: Rest and Serve. Once baked, remove the John Wayne Casserole from the oven. Allow it to rest for a few minutes (about 5-10 minutes) before serving. This brief resting period helps the layers set, making it easier to scoop and ensuring that each slice holds its shape. The anticipation will only make the first bite even more enjoyable!



Preparation and Storage Tips for Your Casserole
The John Wayne Casserole is not only delicious but also incredibly convenient when it comes to make-ahead planning and storage. Here’s how to manage your masterpiece:
Make-Ahead & Storage: Casseroles are the ultimate make-ahead meal, and this recipe is no exception! You can prepare the entire casserole up to the baking step. Simply cover the prepared baking dish tightly with plastic wrap or aluminum foil. Refrigerate it in an airtight container for up to three days. When you’re ready to bake, remove it from the fridge while the oven preheats, then bake as directed, potentially adding an extra 5-10 minutes to the baking time if it’s going into the oven cold.
Freezing & How to Freeze: For longer storage, freeze your leftover casserole in an airtight, freezer-safe container. You can also double-wrap individual portions in plastic wrap and then foil to prevent freezer burn. It will keep well for up to three months. We generally don’t recommend freezing unbaked meat casseroles for food safety reasons, especially with ground beef, unless you are using a plant-based meat alternative designed for freezing raw. Freezing a cooked casserole is always the safest bet.
How to Reheat: Individual refrigerated leftovers reheat beautifully in the microwave. Ensure each portion is heated thoroughly to an internal temperature of 165°F (74°C). For frozen leftovers, it’s best to thaw them in the refrigerator overnight until visibly unfrozen. Once thawed, you can reheat portions in the microwave or the entire casserole in the oven at 300°F (150°C) until warmed through, usually around 20-30 minutes for a full dish.
John Wayne Casserole: Recipe Variations for Every Taste
One of the best qualities of the John Wayne Casserole is its adaptability. Feel free to make it your own with these delicious variations:
Substitutions:
- Ground Beef Alternatives: While ground beef is traditional, you can easily swap it for ground turkey, ground chicken, or even a plant-based meat alternative like Beyond Meat for a lighter or vegetarian option. Each will bring its own unique flavor profile.
- Cheese Choices: Cheddar cheese is classic, but don’t limit yourself! Colby Jack, mozzarella, pepper jack cheese (for a spicy kick), or a Mexican blend are all fantastic alternatives. A blend of two or three cheeses can add wonderful complexity.
- Bell Peppers: While green bell peppers are often used, feel free to use red, yellow, or orange bell peppers for a sweeter flavor and more vibrant color.
Vegetarian and Vegan Options: To make this recipe vegetarian, simply swap the ground beef for a plant-based alternative such as Beyond Meat or a lentil-based crumble. For a fully vegan version, ensure you also use plant-based sour cream, mayonnaise, and cheese substitutes. Bisquick Baking Mix itself is vegan if prepared with suitable plant-based milk and egg substitutes (e.g., flax egg or commercial egg replacer).
Gluten-Free Adaptation: For those with gluten sensitivities or allergies, Bisquick offers a gluten-free baking mix that works perfectly as a direct substitute for the regular mix, allowing you to enjoy this comforting casserole without compromise.
Make it Spicy: If you love a little heat, dial up the spice! Instead of mild Rotel, opt for a hot variety. You can also use a spicy taco seasoning packet, or add a pinch of cayenne pepper, a dash of hot sauce to the meat mixture, or sliced jalapeños (fresh or pickled) to the topping.
Sugar-Free Considerations: The original recipe contains a small amount of sugar (around 12 grams per serving, likely from the Bisquick mix or canned ingredients). While making it completely sugar-free might be challenging without significant alterations, you can certainly choose ingredients with the lowest sugar content possible to reduce your overall consumption.
Expert Tips for the Best John Wayne Casserole
Achieve casserole perfection every time with these valuable tips and tricks:
- Preheat Your Oven: Always preheat your oven to the specified temperature. This seemingly small step is crucial for accurate cooking times and ensures the casserole bakes evenly from the moment it enters the oven.
- Add Onions for Extra Flavor: While not included in the primary ingredient list for simplicity, adding a cup of diced onions to your ground beef as it browns will infuse the meat with an incredible depth of savory flavor. Cook them until softened and translucent before adding the taco seasoning.
- Consider Diced Red Peppers: Don’t hesitate to add diced red bell peppers alongside the green ones for a sweeter flavor profile and a more colorful presentation.
- Alternative Biscuit Base: If you don’t have Bisquick, Pillsbury Grands biscuits can be a suitable alternative. Simply press them together to cover the bottom of the baking dish. For best results, par-bake them for about half their normal baking time (until slightly set but not fully golden) before adding the beef mixture. This helps prevent a soggy bottom.
- Use a Baking Sheet Underneath: As mentioned in the instructions, always place your casserole dish on a baking sheet with sides. When the Bisquick dough bakes and expands, it can push the upper layers of ingredients, including the creamy topping and cheese, higher in the pan. This sometimes causes delicious juices or cheese to bubble over the sides, and a baking sheet will prevent a messy oven.
- Prevent Over-Browning: If you notice the cheese topping getting too dark before the casserole is fully heated through, loosely tent the dish with aluminum foil. This will prevent further browning while allowing the inside to finish cooking.
- Customizing Vegetables: Our recipe focuses on Rotel, corn, and bell peppers, but feel free to experiment. While this recipe does not include potatoes, tater tots, or tomato slices, some variations of “cowboy casseroles” might. Feel free to adapt if those ingredients appeal to you!
- Explore Related Recipes: If you love the creamy elements in this dish, be sure to check out our broader cream cheese recipe collection for more delightful creations.

When to Serve & What to Serve With John Wayne Casserole
Hearty, filling, and incredibly versatile, the John Wayne Casserole isn’t just for dinner. Its robust flavors and satisfying nature make it perfect for breakfast, brunch, or even breakfast-for-dinner! Here are some fantastic menu planning ideas:
Perfect Sides: Complement the rich flavors of the casserole with these delightful sides:
- 2 Ingredient Cinnamon Roll Apple Pie Cups: A sweet and fruity contrast.
- Sausage Breakfast Biscuit Cups: For an extra protein boost, perfect for brunch.
- Cinnamon Roll Waffles: A sweet and crispy pairing.
- Bacon Gravy: For those who crave even more savory richness.
- Easy Pancake Muffins: A lighter, fluffy counterpoint.
- Crock Pot Cinnamon Roll Monkey Bread: A fun, shareable sweet treat.
- Easy Homemade Banana Bread: A classic comfort side.
Hearty Main Dishes (if serving the casserole as a lighter side or for inspiration):
- Easy German Apple Pancake
- French Toast Casserole
- Crock Pot Peaches & Cream Oatmeal
- Apple & Raisin French Toast
- Cracker Barrel Pecan Pancakes
- Crock Pot Carrot Cake Oatmeal
Decadent Desserts (to follow your satisfying casserole):
- Air Fryer Donuts
- Lemon Dutch Baby
- Cinnamon & Sugar Crescents
- Raspberry Coffee Cake
- Biscuit Donuts
More Great Dinner Recipes to Explore
If you loved the ease and flavor of this John Wayne Casserole, you’ll be thrilled to discover more of our favorite dinner ideas, perfect for any night of the week:
- Chicken Bacon Ranch Casserole: A creamy, savory, and incredibly satisfying dish.
- Million Dollar Spaghetti: Layers of pasta, meat sauce, and cheese baked to perfection.
- Ham and Cheese Crescent Roll Casserole: A fantastic option for breakfast, brunch, or a light dinner.
- Chicken Casserole with Ritz Crackers: A buttery, crunchy topping makes this chicken dish a family favorite.
- Pepperoni Pizza Monkey Bread: A fun, pull-apart pizza experience for kids and adults alike.
- Stovetop Meatloaf: Quick and easy meatloaf cooked right on your stovetop.
- Lazy Lasagna: All the flavor of lasagna with significantly less effort.
- Spaghetti Stuffed Garlic Bread: An innovative and delicious way to combine two Italian-American classics.
Be sure to explore all of our Rotel Recipes and Bisquick Recipes for even more easy casserole ideas and family-friendly meals. We’re always working on new and exciting ways to simplify dinner!
Do you love discovering new recipes? Check out our dedicated sections for copycat recipes that mimic your restaurant favorites, indulgent dessert recipes, and our extensive collection of Crock Pot Recipes for effortless cooking.
Stay connected and never miss a delicious update! Follow Tammilee Tips on MSN, Facebook, Instagram, Pinterest, and Twitter for all our latest recipe posts and culinary inspiration.


John Wayne Casserole Recipe
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Ingredients
- 1.5 pounds Ground Beef
- 1 oz Taco seasoning
- 1 cup Water
- 20 oz RO-TEL Diced Tomatoes & Green Chilies 2 cans, drained
- 15 oz Corn Drained
- 1 Green Pepper Diced
- 3 cups Bisquick Baking Mix
- 1 cup Water
- 1 cup Sour Cream
- 1 cup Mayonnaise
- 2 Tablespoon Onion powder
- 1 teaspoon Salt
- 3 cups Cheddar Cheese Shredded
Instructions
- Preheat Oven to 325 degrees F (160 C).
- Brown ground beef in a large pan over medium heat. Break up the ground beef as it cooks.
- Remove the ground beef and drain the grease from the pan. Add the ground beef back into the pan and top with taco seasoning and add in 1 cup of water.
- Simmer for 5 minutes. Add in the Rotel, Green Pepper, and Corn and mix into the ground beef.
- Combine Bisquick Baking Mix and Water and stir until a dough ball forms.
- Grease a 9×13 pan with nonstick spray. Spread Bisquick dough out evenly into the pan.
- Combine sour cream, mayonnaise, onion powder, and salt in a bowl and mix together. Set aside.
- Pour ground beef mixture over the Bisquick dough and spread evenly. Spread sour cream mayo mixture over the beef mixture evenly. Top with cheddar cheese.
- Place casserole dish on top of a baking sheet with sides and bake for 40 minutes. Remove casserole from the oven and allow to sit for a few minutes before serving.
Kitchen Tools
- 9X13 Pan
- Hamburger Mix and Chop
- Cookie Sheets
Nutrition
Calories from Fat 594
